My Mortal Skin Cells My DNA Sequence Salient Features of My DNA  

Some Salient Features of my DNA
In the table below I have pulled out some interesting sequences in my DNA. "SNPs" are short unique sequences of DNA commonly differing among people with commonly-accepted associations with health. I have linked the SNPs to BioTime's GeneCards website for more information. Note, my participation in BioTime's R&D was as a volunteer in a research project and none of the information below should be considered medical advice. You should only make medical decisions based on consultation with your physician.
 
SNP Genotype Gene Comment
rs309375   T/T N/A

This SNP has been associated with large mosquito bites of which I am prone.

rs5882 G/G CETP

I am very fortunate to have this particular DNA code. It is reported that individuals with this sequence have better cognitive function, that is, as much as 70% less risk of Alzheimer's disease during their lifetime (not saying I am smarter than everyone else), and most exciting, it is believed to be a gene associated with extreme longevity, such as that enjoyed by some populations.

rs2542052 C/C APOC3 This genotype is also associated with longevity. A study one population who lived to be 95 years or older showed the people had this DNA profile.
rs3135391 T/T HLA-DRA This gene is involved in the immune system and having the "T" form of DNA from both parents reportedly increases risk of developing multiple sclerosis 3-6 times
rs4430796 A/A HNF1B This DNA variant is reported to be associated with a 38% increased risk for prostate cancer
rs1042522 G/G TP53 Having this DNA type may lead to decreased response to certain drug treatments in stomach and lung cancers, and if smokers, present with accelerated lung decline
rs3135388 T/T HLA-DRA This is another SNP of HLA-DRA gene which increasese risk of developing multiple sclerosis (3-6 times)
rs11012732 G/G MLLT10 This DNA form is reportedly associated with increased risk of developing meningioma
rs17576 A/G MMP9 Having this DNA type is reported to lead to a higher risk of a disease known as chronis obstructive pulmonary disease (COPD) in smokers
rs1265181 G/G N/A This DNA form in a study of Asian people was shown to correlate with increased risk of the skin disorder known as psoriasis
rs17435 T/T MECP2 This DNA type is said to be associated with 40% increased risk for lupus
rs1344706 G/T ZNF804A Carriers of this genotype show slight (10%) increased risk for schizophrenia
rs965513 A/G N/A This genotype associated with 1.7 times increased thyroid cancer risk
rs4474514 A/A KITLG This genotype is associated with over 3-7 times increased risk for the development of testicular cancer. This genotype (A/A), however, is present in 65% of men of Northern or Western European ancestry.
rs2241880 C/T ATG16L1

This genotype is associated with 1.4x increased risk for Crohn's disease in Caucasian population. The form of the gene is reported to correlate with stress on Paneth cells in the intestine and is reported to possibly  result in intestinal fistulas and the need for surgery.

rs7107418 A/A OR6A2 proxy

Carriers of A allele in this genotype, located in the proximity of the gene for Olfactory Receptor 6A, are associated with decreased chance that they dislike the taste of cilantro, perceiving that it tastes like soap, or dirt.

rs5400 C/T SLC2A2

This DNA is associated with the gene for a molecule that transports sugar in and out of cells in the body. Studies on carriers of this genotype have shown association with habitual consumption of sugars, suggesting an underlying glucose-sensing mechanism that regulates food intake. Carriers of this particular genotype are associated with higher sugar consumption.

rs7221412 G/G PER1 proxy

This is one of polymorphisms near a Period Circadian Clock 1 (PER1) gene, which has an influence on the brain’s perception on the time of day and therefore the sleep cycle and wake-up time. Study showed that carriers of G/G genotype usually wakes up one hour later than people with A/A genotype.

rs2230199           C/G           C3

The is one of the “complement protein” genes. They can be associated with increased/decreased risk for age-related macular degeneration (AMD). People with this DNA type have beenassociated with a 60% increase in the chance of developing AMD. In the future, REGENomics will likely have cells prepared ahead of time to repair the cellular damage leading to AMD when they have increased risk. AMD can be devastating. It is the leading cause of blindness in an aging population.

rs8050894           G/G          VKORC1

This SNP is in the gene VKORC1. VKORC1 makes a protein that is a target for blood thinner drug called warfarin. Based on the version of this gene people carry, physicians may one day determine the daily dosage of the drug to best meet the needs of patients.

rs910873              A/G  PIGU

The “G” version of this gene is associated with increased risk in developing melanoma.

rs601338 A/A FUT2 People with the “A” version of this gene from both parents (A/A) have been reported to have reduced risk to getting a serious Norovirus infection. Gastroenteritis caused by Norovirus is commonly known as 'cruise ship' gastroenteritis.
rs6505162 A/A NSRP1

This (A/A) is a 'protective' genotype  - Having the variant “A” from both parents is reported to reduce the risk of developing esophageal cancer by about half.

rs1024611 C/T   CCL2 promoter

This SNP is in the promoter region of gene CCL2 (just before the start of the gene). Having this form of the gene is reported to influence expression levels of that gene. Carriers are reportedly associated with increase in instances of exercise-induced ischemia (cramps).

rs37973 A/G GLCCI1 In asthmatic patients, carriers of DNA having one “A” from one parent and a “G” from the other (A/G genotypes) have 50% more chance to experience lesser response to inhaled glucocorticoid drugs.
rs3923809 A/G BTBD9 People with this version of the gene are reported to almost double the risk of developing restless legs syndrome.
rs4481887 A/G N/A Carriers with this DNA type are more likely to be able to smell asparagus metabolites in urine  1.67x more likely than people with (G;G) to be able to smell the methanethiol produced after eating asparagus. Why people study things like this is beyond me.
(rs4988235
or
(rs4988235
or
(rs182549
or
(rs182549

C/T)

T/T)

C/T)

T/T)

N/A

People without this combination are more likely to be lactose intolerant.

(rs762551
and
(not (rs12720461
not (rs2069526
not(rs28399424

A/A)

T),
G),
T))

N/A Caffeine is metabolized fast, so carrier is less stimulated by it.
(rs10246939
or
(rs713598
or
(rs1726866

C)

C)

C)

N/A Carrier has normal ability to taste bitter. This means that, for the carrier, cabbage, broccoli, etc. doesn't taste bland.